Abstract Full Text:PDF Recommended articles Mail to Author How to Cite

¹ Department of Biology, Faculty of Engineering and Natural Sciences, Manisa Celal Bayar University, Manisa, Türkiye
² Department of Medical Genetics, Faculty of Medicine, Manisa Celal Bayar University, Manisa, Türkiye DOI : 10.38042/biotechstudies.1672789 - Aquilaria agallocha Roxb. has traditionally been used to treat various medical conditions, including inflammation, fever, and cardioprotection. However, limited studies have explored its specific effects on cancer cells while distinguishing its impact on normal cells. This study aimed to evaluate the effects of A. agallocha heartwood extracts on both normal and cancer cells. To achieve this, mouse L929 (normal), 67NR, and 4T1 (cancer) cells were treated with methanol and ethanol extracts of A. agallocha heartwood to assess cytotoxicity, apoptosis, and oxidative stress. Flow cytometry analysis revealed that both extracts induced apoptosis and oxidative stress in all tested cell lines. However, the extracts exhibited a greater cytotoxic effect on normal L929 cells, potentially due to their bioactive components exerting a stronger pro-oxidant effect. These findings suggest that A. agallocha extracts may differentially affect normal and cancer cells, highlighting the need for further investigation into their selective cytotoxicity. Keywords : Aquilaria agallocha Roxb Breast cancer Apoptosis Oxidative stress