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¹ Ege University, Graduate School of Natural and Applied Sciences, Department of Biomedical Technologies, İzmir, Türkiye
² Ege University, Graduate School of Natural and Applied Sciences, Department of Bioengineering, İzmir, Türkiye DOI : 10.38042/biotechstudies.1673540 - Nanofiber wound dressings are developed using various polymers and adding different active agents to the polymers during the production phase. In this study, PLGA, PLGA containing silver nanoparticles (AgNP/PLGA), PLGA nanofibers containing 1%, 2%, 3% licorice root, and silver nanoparticle doped (LR-AgNP/PLGA) were produced by electrospinning method. The green synthesis method was used to produce licorice-containing silver nanoparticles (LR-AgNP). The morphological analysis of nanofibers was determined using diameter measurements on SEM images. The average fiber diameters of PLGA, AgNP/PLGA, and LR-AgNP/PLGA nanofibers are 344 nm, 260 nm, and 357 nm, respectively. FTIR analysis was used for the determination of chemical bonds. The FTIR graph of PLGA, AgNP/PLGA and LR-AgNP/PLGA nanofibers showed similar peaks in the 3008-2883 cm-1, 1500-1412 cm-1, 1181-1086 cm-1 and 1755-1750 cm-1 bands. The wound healing potential of the produced nanofibers was evaluated on an in vitro wound scratch model. According to the results obtained, LR-AgNP/PLGA nanofibers showed the fastest wound closure. As a result of these studies, it was determined that PLGA nanofibers with silver nanoparticles containing licorice root extract could accelerate the wound healing process. Keywords : Electrospinning Wound healing Nanofibers Silver nanoparticle doped PLGA